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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract:

Neural tube defects (NTDs) are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.

Keywords： planar cell polarity     neural tube defects     rare mutations    

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Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine   Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia     Identification novel mutations    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingTherefore, this review aimed to classify the management of NSCLC with driver mutations based on the geneThirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutictreatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutationsThis review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 51-59 doi: 10.1007/s11684-019-0720-x

Abstract: with mutations and the relation between mutations and tuberculosis (TB) transmission.Twenty-nine nonsynonymous single mutations and three double mutations were identified.The mutations at locus 483 (11.3%) were predominant, and the mutations at V483G, W484G, I491V, L516PFifteen new mutations in the gene were identified.Rifampin resistance and mutations at locus 531 were significantly associated with mutations.

Keywords： tuberculosis     drug resistance     compensatory mutations     transmission    

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Distinct community assembly processes underlie significant spatiotemporal dynamics of abundant and rare

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-021-1513-4

Abstract:

• Season and landform influenced spatiotemporal patterns of abundant and rare

Keywords： Rare taxa     Biogeography     Community assembly     Bacterioplankton     The Yangtze River    

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122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutationsHBV mutations were determined by direct sequencing.Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (HBV) mutations    

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Recovery of rare and precious metals from urban mines—A review

Mengmeng Wang, Quanyin Tan, Joseph F. Chiang, Jinhui Li

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 5, doi: 10.1007/s11783-017-0963-1

Abstract: The recovery of rare and precious metals (RPMs) from urban mines has attracted increasing attention from

Keywords： Rare and precious metals (RPMs)     Distribution characteristics     Recycling technology     Emerging technology    

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Characteristics and Exploitation of Rare Earth,Rare Metal and Rare-Scattered Element Minerals in China

Wang Denghong, Sun Yan, Dai Hongzhang, Guo Weiming, Zhao Zhi, Zhao Ting,Li Jiankang, Wang Chenghui, Huang Fan, Yu Yang, Li Dexian

Strategic Study of CAE 2019, Volume 21, Issue 1,   Pages 119-127 doi: 10.15302/J-SSCAE-2019.01.017

Abstract:

China is rich in rear earth, rear metal, and rare-scattered element (suggestions for their development and utilization, and further emphasize the basic idea that “rareearth should be regulated, rare metal should be found when needed, and rare-scattered elements should

Keywords： rare earth     rear metal     and rare-scattered element minerals     resource characteristics     exploitation    

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Migration of ammonium nitrogen in ion-absorbed rare earth soils during and post mining: a column study

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1702-4

Abstract:

● Column experiments with an inclined slope were applied to simulate NH4–N transport.

Keywords： Ion-absorbed rare earth     Ammonium nitrogen transport     HYDRUS-2D     Numerical simulation    

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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: Although rare tumors account for a non-negligible number, the practice of precision medicine and developmentHerein, by reviewing the epidemiological data of Chinese solid tumors and publications defining raretumors in other areas, we proposed a definition of rare tumor in China, including 515 tumor types withLastly, we pinpointed the current recommendation chance for patients with rare tumors to be involvedand guarantee a bright future for rare tumor patients.

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide     APL     rhabdomyolysis    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemiaHowever, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlybased on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutationswere mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1584-1594 doi: 10.1007/s11705-022-2189-4

Abstract: The separation of rare earth elements is particularly difficult due to their similar physicochemicalThe differences of the ionic magnetic moment among rare earths are greater than that of ionic radius.Herein, a novel method based on the large ionic magnetic moment differences of rare earth elements wasRare earths were firstly dissolved in the ionic liquid, then the ordering degree of them was improvedthe Z-bond effect, and finally the magnetic moment differences between paramagnetic and diamagnetic rare

Keywords： rare earth element     different magnetic moment     magnetic separation     ionic liquid    

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Assessment of leaching behavior and human bioaccessibility of rare earth elements in typical hospital

Chunfeng Wang, Guanfei Chen, Yanchen Zhu, Dan Yao, Wanfeng Wang, Lianjun Wang

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0946-2

Abstract: Leaching behavior and gastrointestinal bioaccessibility of rare earth elements (REEs) from hospital waste

Keywords： Assessment     Rare earth elements     Leaching behavior     Bioaccessibility     Hospital waste    

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Preparation of rare-earth metal complex oxide catalysts for catalytic wet air oxidation

LI Ning, LI Guangming, YAO Zhenya, ZHAO Jianfu

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 2,   Pages 190-195 doi: 10.1007/s11783-007-0033-1

Abstract: Catalytic wet air oxidation (CWAO) is one of the most promising technologies for pollution abatement. Developing catalysts with high activity and stability is crucial for the application of the CWAO process. The Mn/Ce complex oxide catalysts for CWAO of high concentration phenolcontaining wastewater were prepared by coprecipitation. The catalyst preparation conditions were optimized by using an orthogonal layout method and single-factor experimental analysis. The Mn/Ce serial catalysts were characterized by Brunauer Emmett Teller (BET) analysis and the metal cation leaching was measured by inductively coupled plasma torch-atomic emission spectrometry (ICP-AES). The results show that the catalysts have high catalytic activities even at a low temperature (80?C) and low oxygen partial pressure (0.5 MPa) in a batch reactor. The metallic ion leaching is comparatively low (Mn<6.577 mg/L and Ce<0.6910 mg/L, respectively) in the CWAO process. The phenol, COD, and TOC removal efficiencies in the solution exceed 98.5% using the optimal catalyst (named CSP). The new catalyst would have a promising application in CWAO treatment of high concentration organic wastewater.

Keywords： torch-atomic emission     Brunauer     Catalytic     process     stability    

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Title Author Date Type Operation

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Journal Article

Distinct community assembly processes underlie significant spatiotemporal dynamics of abundant and rare

Journal Article

122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Recovery of rare and precious metals from urban mines—A review

Mengmeng Wang, Quanyin Tan, Joseph F. Chiang, Jinhui Li

Journal Article

Characteristics and Exploitation of Rare Earth,Rare Metal and Rare-Scattered Element Minerals in China

Wang Denghong, Sun Yan, Dai Hongzhang, Guo Weiming, Zhao Zhi, Zhao Ting,Li Jiankang, Wang Chenghui, Huang Fan, Yu Yang, Li Dexian

Journal Article

Migration of ammonium nitrogen in ion-absorbed rare earth soils during and post mining: a column study

Journal Article

Rare tumors: a blue ocean of investigation

Journal Article

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

Journal Article

Assessment of leaching behavior and human bioaccessibility of rare earth elements in typical hospital

Chunfeng Wang, Guanfei Chen, Yanchen Zhu, Dan Yao, Wanfeng Wang, Lianjun Wang

Journal Article

Preparation of rare-earth metal complex oxide catalysts for catalytic wet air oxidation

LI Ning, LI Guangming, YAO Zhenya, ZHAO Jianfu

Journal Article